Despite having undergone 9 rounds of relatively successful chelation with IV DMPS, this weekend I decided to try Dimercaptosuccinic acid (DMSA). I wanted to try it because I wanted to see if the side effects were better worse than DMPS. On DMPS I would generally feel quite good for one to three days followed by a slow buildup of redistribution symptoms. There is a fervent following of people on the Cutler protocol who believe that frequent low-dose chelation is the best and safest way to chelate, so I felt that given the amount of perceived success people have experienced it was worth trying.
I strictly adhered to the half-life based protocol of 100 mg DMSA every 4 hours. The goal was to get 3 full days of chelation in which would effectively be similar to an IV DMPS treatment in terms of chelation efficiency.
Overall, I was not too impressed with DMSA as a chelator. I experienced a lot of discomfort with redistribution effects primarily with stocking/gloves nerve pain, muscle spasms, heart palpitations and kidney stress. Generally, I can deal with a bit of heart palpitations, spasms and parasthesia. These have been transient with chelation.
Protecting against Nephrotoxicity caused by Mercury
My biggest concern is with kidney stress as the kidneys are fragile. Long-term inflammation can cause scarring and permanent damage. Obviously not a good thing. My strategy to counteract this is fairly straightforward: Prevent Nephrotoxicity caused by Mercury.
- Taurine - Has been shown to prevent nephrotoxicity and oxidative stress.
- Vitamin C - Antioxidant with chelating properties at sufficient doses also helps to prevent neurotoxicity
- Vitamin E - Another antioxidant with nephro-protective effects
Bentonite Clay Detox Baths
Additionally, I have embraced bentonite clay baths as my secondary detoxification modality. Clay baths have been very effective at reducing my parasthesia and heart palpitations. While on DMSA, the deposits in the clay residue after the bath was markedly different than with DMPS. It had a reddish rusty tint to it, which make sense since DMSA can be used to chelate iron1.
DMPS or DMSA?
In the immediate future I plan to give my kidneys a break, at least 2 weeks to let my kidneys heal a bit. Then I will return to DMPS. My body seemed to tolerate DMPS much better than DMSA. The efficiency of DMPS seems to cause fewer side effects when compared to DMSA. Since DMSA is not as efficient a chelator as DMPS, it seems to let a drop a few more molecules of mercury into places where I do not want it. At some point down the road, probably after 20 rounds of IV DMPS, I will probably re-evaluate and start the DMSA/ALA protocol to remove mercury from my brain. Until then, I’m going to return to the more comfortable chelator, DMPS.
1: Hider, Robert C.; Kong, Xiaole (2013). “Chapter 8. Iron: Effect of Overload and Deficiency”. In Astrid Sigel, Helmut Sigel and Roland K. O. Sigel. Interrelations between Essential Metal Ions and Human Diseases. Metal Ions in Life Sciences 13. Springer. pp. 229–294. doi:10.1007/978-94-007-7500-8_8.